Research Project Level Inventory by Agents under study then Organisms
Agent Types: Estrogens/Anti-Estrogens
Category: Invertebrates(7)- Assessment of reproductive, immunological and (geno)toxic impact of
- Ocurrence of nonylphenol and nonylphenol polyethoxylates in Canadian aquatic
- Examination of white sucker populations for evidence of reproductive and
- Continued studies examining white sucker populations for evidence of recovery
- Life-cycle tests with fish
- Metabolic Androgenization of Invertebrates by Endocrine-Disrupting Chemicals
- Development of a bioassay with Marisa cornuarietis (Gastropoda:Prosobranchia) for the assessment of environmental chemicals withhormone-mimetic effects
- Examination of fish for evidence of estrogenic responses downstream of Ontario
- Examination of white sucker populations for evidence of reproductive and
- Plasma Vitellogenin Measurements in Fish from the Fraser River Basin
- Continued studies examining white sucker populations for evidence of recovery
- Examination of fish exposed to agricultural runoffs for evidence of endocrine
- Endocrine Disruptors in German Waterways
- A field evaluation of reproductive endocrine alterations in fish exposed to
- Xenoestrogenic Screening Procedure to Identify Substances of Concern
- Endocrine test development
- Environmental Effects of Industrial Effluents
- Life-cycle tests with fish
- Effects of Municipal effluents
- ESTABLISHMENT OF AN IN VIVO EMBRYONIC SYSTEM FOR THE ASSESSMENT OF MOLECULAR AND CELLULAR EFFECTS OF ENDOCRINE MODULATION COMPOUNDS
- A short-term in vivo screening system for endocrine disruptors utilizing mosquitofishes (Gambusia affinis and G. holbrooki)
- In Vitro Methods to Assess Reproductive/Developmental Risk of Environmental Contaminants to Aquatic Organisms
- Endocrine Disruption among coastal fish species
- Development of Molecular Indicators of Exposure to Pesticides and Endocrine Disrupting Compounds
- Examination of the estrogen response pathway in a new vertebrate model
- FIELD VALIDATION OF VITELLOGENIN INDUCTION IN FERAL MALE FISH AS AN INDICATOR OF EXPOSURE TO ESTROGENIC COMPOUNDS.
- LABORATORY ASSESSMENT OF VARIABILITY ASSOCIATED WITH MEASURMENTS OF VITELLOGENIN AND BRAIN AROMATASE ACTIVITY IN FISH3. Project Focus: ECOLOGICAL EFFECTS, EXPOSURE ASSESSMENT
- An in vivo model for detection of reproductive effects of endocrine disruptors
- Development and validation of a user-friendly, mass-screening assay for aquatic endocrine disruptors
- Species-Specific Endocrine Disruption: PCB- and PAH-Induced Estrogenic Effects
- Endocrine disruption in the marine environment (EDMAR)
- Xenoestrogen effects during premeiotic stages of spermatogenesis: Development of an invitro test system and molecular markers of action
- Immune, Reproductive and Histologic Evaluation in Fish Collected for the Columbia and Rio Grande Basins BEST Program.
- Evaluation of Selected Histologic and Immunologic Biomarkers in Fish Collected for the BEST Pilot Program in the Mississippi Drainage
- Development, characterization, and validation of an in vivo model for evaluating the effects of endocrine disrupting chemicals on sexual differentiation and development in fish.
- XENOESTROGENIC SCREENING PROCEDURE TO IDENTIFY SUBSTANCES OF CONCERN
- Effects of Organochlorine Contaminants on Avian Endocrine Systems
- Critical Stages in Sublethal Exposure to EDCs in a Quail Model System
- Critical Stages in Avian Development: Estrogenic Hazards to Altricial and Precocial Birds
- Steroid concentrations and organochlorine residues in eggs of Common terns.
- Environmental Endocrine Disruption in Avian Wildlife
- 06995-03 TOXICITY OF ENVIRONMENTAL ESTROGENS
- HORMONALLY-MEDIATED ALTERATION OF HEPATIC CYTOCHROME P450 EXPRESSION BY TAMOXIFEN
- MEASUREMENT OF ESTROGENIC EFFECTS OF MATERIALS ASSOCIATED WITH MEDICAL DEVICES:DEVELOPMENT OF A MOLECULAR ASSAY FOR ESTROGENIC EFFECTS
- BIOLOGICAL RESPONSES TO PARTICULATE MATERIAL
- Effects of early exposure to xenoestrogens on the prostate gland
- Biochemical and reproductive effects of gestational/lactational exposure to PCB's with respect to endogenous sex steroids and the proestrogen, methoxychlor
- Identifying neurotoxic action of endocrine disruptors
- EFFECTS OF ENVIRONMENTAL TOXICANTS ON THE STEROID HORMONE PATHWAY
- Environment-dependent brain development mediated by hormones andneurotransmitters Environment-dependent brain development mediated by hormones andneurotransmitters Environment-dependent brain development mediated by hormones andneurotransmitters
- Influence of Plasma Sex Hormone Binding Globulin on the Bioavailability of Phytoestrogens and Xenobiotics
- Assessment of the Endocrine Disrupting Potential of Chemicals in Environmental
- 58223-04 SPORE IN BREAST CANCER
- 63748-03 ORAL CONTRACEPTIVES AND OVARIAN CANCER
- HORMONALLY-MEDIATED ALTERATION OF HEPATIC CYTOCHROME P450 EXPRESSION BY TAMOXIFEN
- 66016-01 EFFECTS OF SOY CONSUMPTION ON ESTROGEN IN WOMEN
- Development of in vitro human cell culture systems to screen compounds expected to have estrogenic or anti-estrogenic activity.
- DNA Addutcts of Tamoxifen
- Analyssi of residue levels of endocrine disruptor in human umbilical cords & fetus
- Species-Specific Endocrine Disruption: PCB- and PAH-Induced Estrogenic Effects
- Epidemiological Study of Testicular Cancer
- Environment-dependent brain development mediated by hormones andneurotransmitters Environment-dependent brain development mediated by hormones andneurotransmitters Environment-dependent brain development mediated by hormones andneurotransmitters
- Assessment of reproductive, immunological and (geno)toxic impact of
- Plasma Vitellogenin Measurements in Fish from the Fraser River Basin
- Effects of Organochlorine Contaminants on Avian Endocrine Systems
- Endocrine Disruptors in German Waterways
- A field evaluation of reproductive endocrine alterations in fish exposed to
- Xenoestrogenic Screening Procedure to Identify Substances of Concern
- Endocrine test development
- Environmental Effects of Industrial Effluents
- Life-cycle tests with fish
- 06995-03 TOXICITY OF ENVIRONMENTAL ESTROGENS
- 07621-03 VITELLOGENIN AS A BIOMARKER FOR ESTROGENIC XENOBIOTICS
- 25001-20 ROLE OF MUTAGENESIS IN CARCINOGENESIS
- ROLE OF ESTROGEN AND RETINOIC ACID IN HUMAN BREAST CANCER CELL GROWTH AND PROGRAMMED CELL DEATH. ROLE OF RETINOIC ACID IN DIFFERENTIATION OF EMBRYONAL CARCINOMA CELLS.
- ESTABLISHMENT OF AN IN VIVO EMBRYONIC SYSTEM FOR THE ASSESSMENT OF MOLECULAR AND CELLULAR EFFECTS OF ENDOCRINE MODULATION COMPOUNDS
- DEVELOPMENT OF A BIOASSAY FOR ENVIRONMENTAL ESTROGENS
- CELLULAR AND MOLECULAR MECHANISMS OF ABNORMAL REPRODUCTIVE DEVELOPMENT: IN VIVO EFFECTS OF ENVIRONMENTAL ESTROGENS
- ANTIBODY REAGENTS FOR RECEPTOR-BASED BIOSENSORS
- Protective Influence of Melatonin on Proliferation in Breast Cancer Cells
- Endocrine Disruptor Knowledge Base
- DNA Addutcts of Tamoxifen
- Effects of early exposure to xenoestrogens on the prostate gland
- VALIDATION OF AN IN VITRO RAT UTERINE ESTROGEN RECEPTOR BINDING ASSAY TO GENERATE RBA DATA FOR USE IN 3D-QSAR MODELING OF POTENTIAL ENDOCRINE DISRUPTORS
- Evaluation of endocrine disruption in fish and aquatic invertebrates.
- A short-term in vivo screening system for endocrine disruptors utilizing mosquitofishes (Gambusia affinis and G. holbrooki)
- Critical Stages in Sublethal Exposure to EDCs in a Quail Model System
- Dioxin and Steroid Regulation in an Endometriosis Model
- Biochemical and reproductive effects of gestational/lactational exposure to PCB's with respect to endogenous sex steroids and the proestrogen, methoxychlor
- Endocrine Disruptors and Host Resistance in Lake Apopka Alligators
- Critical Stages in Avian Development: Estrogenic Hazards to Altricial and Precocial Birds
- In Vitro Methods to Assess Reproductive/Developmental Risk of Environmental Contaminants to Aquatic Organisms
- Endocrine Disruption among coastal fish species
- Pilot Field Study to Refine the Measurement and Methods of Fifteen Suspect Endocrine Disrupting Compounds in the Neuse River Basin
- Use of a Hybrid Multimedia Compartmental Model to Assist Field Monitoring Project Design for Endocrine Disruptor Detection, Media Concentration, Exposure Model Development and/or Model Confirmation and to Support Fate and Transport Endocrine Disruptor Exposure (EDE) Research
- Development of Molecular Indicators of Exposure to Pesticides and Endocrine Disrupting Compounds
- Examination of the estrogen response pathway in a new vertebrate model
- FIELD VALIDATION OF VITELLOGENIN INDUCTION IN FERAL MALE FISH AS AN INDICATOR OF EXPOSURE TO ESTROGENIC COMPOUNDS.
- LABORATORY ASSESSMENT OF VARIABILITY ASSOCIATED WITH MEASURMENTS OF VITELLOGENIN AND BRAIN AROMATASE ACTIVITY IN FISH3. Project Focus: ECOLOGICAL EFFECTS, EXPOSURE ASSESSMENT
- Steroid concentrations and organochlorine residues in eggs of Common terns.
- An in vivo model for detection of reproductive effects of endocrine disruptors
- Endocrine disruption in Pacific Tree Frogs
- Occurrence of selected endocrine disruptive chemicals and their association with congenital anomalies of the Florida panther.
- Identifying neurotoxic action of endocrine disruptors
- Methoxychlor and environmental "estrogen" receptors in ERa-minus mice"
- Species-Specific Endocrine Disruption: PCB- and PAH-Induced Estrogenic Effects
- Reproductive and endicrine effects of o,p'-DDT, an environmental estrogen, and p,p'-DDE, and environmental antiandrogen, in male and female atlantic croaker during criticaliod
- Metabolic Androgenization of Invertebrates by Endocrine-Disrupting Chemicals
- Endocrine Disruption in the Marine Environment (EDMAR)
- Release and fate of estrogenic and (anti)androgenic substances into theaquatic environment Release and fate of estrogenic and (anti)androgenic substances into theaquatic environment
- Endocrine disruption in the marine environment (EDMAR)
- Environmental Endocrine Disruption in Avian Wildlife
- Xenoestrogen effects during premeiotic stages of spermatogenesis: Development of an invitro test system and molecular markers of action
- Environment-dependent brain development mediated by hormones andneurotransmitters Environment-dependent brain development mediated by hormones andneurotransmitters Environment-dependent brain development mediated by hormones andneurotransmitters
- Amphibians as a model to study endocrine disruptors
- Development of a bioassay with Marisa cornuarietis (Gastropoda:Prosobranchia) for the assessment of environmental chemicals withhormone-mimetic effects
- Immune, Reproductive and Histologic Evaluation in Fish Collected for the Columbia and Rio Grande Basins BEST Program.
- Evaluation of Selected Histologic and Immunologic Biomarkers in Fish Collected for the BEST Pilot Program in the Mississippi Drainage
- Development, characterization, and validation of an in vivo model for evaluating the effects of endocrine disrupting chemicals on sexual differentiation and development in fish.
- Ex Vivo/In Vitro Testes and Ovary Assay: Evaluation of its Utility to Identify Steroid Biosynthesis Inhibitors
- Endocrine Screening Battery
- Estrogen Receptor-Beta Activation of Prolactin Gene Expression
- The Role of Estrogen Receptor in Aggressive Behavior
- Interaction of Chemicals and Endocrine Receptors/ Molecular Models
- Identification of biomedical endpoints of estrogen action in the male rat with possible confirmation in a primate model and in man
- Effect of endocrine disruptors on highly integrated systems.
- Endocrine Disruption in the Marine Environment : EDMAR
- Environmental Estrogens and the neuroendocrine regulation of reproduction in fish
- A short-term screen for endocrine disruption in juvenile fathead minnows (Pimephales promelas)
- Effects of endocrine-disrupting chemicals on reproductive function of fish
- Effects of endocrine disrupting chemicals on immune systems function in estuarine fishes
- NATIONAL INVESTIGATION INTO THE OCCURRENCE AND EFFECTS OF ESTROGENIC-ACTIVE COMPOUNDS IN THE AQUATIC ENVIRONMENT
- Effects of an endocrine disruptor on prostate development and growth
- Developmental Exposure to Endocrine Disruptors: Fertility and Gene Expression Profiles
- Effects of Endocrine Disruptors on Mammalian Testis Development
- Endocrine Disruption in Marine Gastropods by Environmental Chemical Mixtures
- Analyses on the effect of ECDs on the estrogen metabolism and possible application to screening.
- Effects of endocrine disrupting chemicals on neuronal stem-cell differentiation
- Effects of fetal and neonatal exposure to EDCs on the structural alterations of Hypothalamic nuclei and the influence on the reproduction.
- Effects of estrogenic compounds on early development of the chick embryo
- The study on the effects of endocrine disrupting chemicals on steroid hormone receptors
- Carcinogenic effect of endocrine disrupting chemicals
- Sex steroid hormone metabolism: enzyme and receptor expression in human tissues
- Effects of endocrine disrupting chemicals on the thyroid carcinogenesis.
- Basic studies on the OECD GL407 as an EDC assay
- 3D-QSAR of EDCs, by computer simulation system using the docking method.
- Biological and molecular aspects of EDCs with a special reference to 3D-QSAR analysis.
- Application of Surface Plasmon Resonanse method to high through put screening
- Development of detection system for endocrine disruptors with special reference to its mechanisms
- A study on the validation of high through put systems using reporter gene assay system and surface plasmon resonance method
- Molecular mechanism of receptor-mediated endocrine disrupting chemicals
- A novel in vivo screening method on ECDs, an application of alpha2u-globulin to EDC screening.
- Development of screening system on the hormone receptor-mediated EDCs by yeast two-hybrid system.
- Development and validation of high through put screening using human cell reporter gene assay.
- OECD validation studies
- OECD validation studies-extended
- Development of effective bioassay system for endocrine dirsuptors in the workplace.
- Study of the mechanism of endocrine disruptors on gene expression of C. elegans
- Effects of endocrine disruptors on chemokine production.
- Cross-talk of signal transduction of endocrine disruptors between arylhydrocarbone and steroid hormone receptors
- Development of a EDC screening system using sex-differentiation related gene expression in chick embryo
- The effects of hormones and EDCs on nueronal network
- Effects of EDCs on the uterine carcinogenesis model
- Development of a high-sensitivity analysis method and its application to monitoring of chemical concentrations in the environment.
- Studies on induction mechanism of imposex in gastropods
- Effects on reproductive disorders in fish
- Development of EDC screening method using cell line transfected with human estrogen receptor gene.
- Refinement of Yeast Two-hybrid system on EDC screening
- A study on the effect of untrauterine exposure on the reproduction of the next generation (F2).
- Development of bioassay system of EDC effects on fish.
- Development of bioassay system of EDC effects on fish.
- Establishment of biological methods to monitor endocrine disruptions in aquatic wildlife
- Effects of endocrine disrupting chemicals on central neuronal system and germ cells
- Identification and characterization of endocrine activity in vitro and in acute in vivo tests
- In vitro analysis of endocrine activity of environmental samples and of mixtures of chemicals
- Endocrine active chemicals and sexual differentiation of central nervous system and genital tract organs: Steroid hormone-regulated genes
- The effect of oestrogenic compounds on the life history of the pond snail Lymnaea stagnalis
- Strategies for detection of enviromental endocrine disruptors in animals and in humans.
- Early life stage exposure to environmental oesrtogens in relation to reproductive and developmental ecology of model and commercially important species
- The influence of environmental oestrogens on vitellogenesis in crustaceans
- Temperature--Not Chromosomes--Determines the Gender of Certain Lower Vertebrates
- Bioindicators of exposure to and effects of xenoestrogens in the marine environment
- Development of a sensitive assay for androgenic activity using prostate cell lines
- CYTOCHROME P450 AND CANCER CHEMOTHERAPY
- Combined effect of representative EDCs in uterotrophic, hershberger and modified one generation assays (contract study)
- Effects of endocrine disrupting chemicals on mouse gonad differentiation, spermgenesis and oogeuesis
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