Study Types: Alkylphenols

• Physiological effects of xenobiotic oestrogens in mammals
• Emulation of sex steroid receptor action in yeast
• Endocrine modulators and the human female reproductive system
• xenoestrogens and sperm quality in man
• toxicokinetics of p-tert-octylphenol in male Wistar rats
• Environment and male reproductive health
• Etiologic Factors in Breast Cancer: Estrogenic Xenobiotics in fat tissue (A case control study)
• Cryptorchidism and xenoestrogens. Is there an assiciation?
• Endocrine Disruptors and Human Male Reproduction
• Hormone Disruptors in Food
• Neurobiology of Behaviour
• ATSDR TOXICOLOGICAL PROFILES
• DEVELOPMENT OF A BIOASSAY FOR ENVIRONMENTAL ESTROGENS
• ENHANCEMENT OF PRECLINICAL TOXICOLOGY CHARACTERIZATION METHODS TO EVALUATEREPRODUCTIVE HAZARDS IN THE NAVY WORKPLACE.
• HYPOTHALAMIC SLICE AS A MODEL FOR TESTING THE EFFECTS OF CHEMICALS.
• CELLULAR AND MOLECULAR MECHANISMS OF ABNORMAL REPRODUCTIVEDEVELOPMENT
• Endocrine Disruptor Knowledge Base
• Effects of early exposure to xenoestrogens on the prostate gland
• VALIDATION OF AN IN VITRO RAT UTERINE ESTROGEN RECEPTOR BINDING ASSAY TO GENERATE RBA DATA FOR USE IN 3D-QSAR MODELING OF POTENTIAL ENDOCRINE DISRUPTORS
• EFFECTS OF ENVIRONMENTAL TOXICANTS ON THE STEROID HORMONE PATHWAY
• Endocrine disruption in the marine environment (EDMAR)
• Environment-dependent brain development mediated by hormones andneurotransmitters Environment-dependent brain development mediated by hormones andneurotransmitters Environment-dependent brain development mediated by hormones andneurotransmitters
• Prediction In Vitro of the Bioactivity of Potential Xenoestrogens in Animals and Humans
• Do industrial estrogens or their metabolites influence male reproductive function ? A pilot study using mammalian cell lines.
• Developmental Exposure to Endocrine Disruptors: Fertility and Gene Expression Profiles
• Development of in vitro system exhibiting human metabolic enzyme systems that modify the EDC molecules
• Development of screening system on the hormone receptor-mediated EDCs by yeast two-hybrid system.
• Development and validation of high through put screening using human cell reporter gene assay.
• Development of EDC screening method using cell line transfected with human estrogen receptor gene.
• Refinement of Yeast Two-hybrid system on EDC screening
• Development of bioassay system of EDC effects on fish.
• Endocrine active chemicals and sexual differentiation of central nervous system and genital tract organs: Steroid hormone-regulated genes
• Human exposure to xenobiotics with potential endocine effects: evaluation of risks for reproduction and development
• Human exposure to xenobiotics with potential endocrine effects: evaluation of risks for reproduction and development
• Strategies for detection of enviromental endocrine disruptors in animals and in humans.
• Professional exposure (Greenhouse workers and sprayers) to pesticides
• Combined effect of representative EDCs in uterotrophic, hershberger and modified one generation assays (contract study)
• organochlorines and male reproduction

• Vitellogenin assay with fish hepatocytes
• Estrogenous effects of xenobiotics: Trial run of an in vitro testsystem for detecting estrogenous effects of xenobiotics with genetically engineered yeast
• Effects of Oestrogenic Substances in the Aquatic Environment
• Environmental Chemicals as endocrine disruptors: Amphibians as a model to study the feminization phenomenon
• Effect of endocrine disruptors on sexual differentiation of the brain in mammals
• Aquatic ecotoxicology
• Environmental halogenated aromatic hydrocarbons and estrogens; mechanism of action, interactions and test-system development
• Effects of environmental estrogens on marine organisms
• Development of a vitellogenin assay with fish hepatocytes
• Endocrine-disrupting effects on amphibia
• Development of a Fish Test to Detect Endocrine Disruptors in Surface Water
• Detection of environmental contaminants with estrogenic effects by means of isolated fish hepatocytes
• Assessment, management and substitution of hormonally active substances
• Effects of environmental pollutants on fish reproduction
• Review of the evidence for ecological effects of environmental sex hormone disrupters
• 1) Investigation of wild populations of fish to determine evidence of endocrine disruption 2) Effects of endocrine disruptors on early life stages of fish 3) Effects of sewage effluents on sex differentiation
• Effects of oestrogen modulators on sex developement of birds
• Endocrine chemicals in fish and fish cells - strategies for ecotoxicological testing
• Ecotoxicological relevance of endocrine reactive compounds in the aquatic environment. Investigations along the Elbe River as a model
• Assessment of the Endocrine Disrupting Potential of Chemicals in Environmental
• QSAR, development & application of QSARs
• Environmental Effects of Industrial Effluents
• Life-cycle tests with fish
• Effects of Municipal effluents
• Fate & effects of reproductive endocrine disruptors in the aquatic environment
• IMMUNOTOXICITY OF ORGANOCHLORINE COMPOUNDS IN WILDLIFE SPECIES
• COMPARATIVE TOXICOLOGY AND ENDOCRINOLOGY OF AMPHIBIANS
• Evaluation of endocrine disruption in fish and aquatic invertebrates.
• Critical Stages in Avian Development: Estrogenic Hazards to Altricial and Precocial Birds
• In Vitro Methods to Assess Reproductive/Developmental Risk of Environmental Contaminants to Aquatic Organisms
• Endocrine Disruption among coastal fish species
• INVERTEBRATE MODELS FOR ASSESSING THE DEVELOPMENTAL ANDREPRODUCTIVE EFFECTS OF CONTAMINANTS
• DEVELOPMENT OF SMALL FISH MODELS FOR ASSESSING DEVELOPMENTAL AND REPRODUCTIVE TOXICITY
• COMPARISON OF TWO IN-VITRO AND AN IN-VIVO FISH VITELLOGEN ASSAY.
• DEVELOPMENT OF AN IN VIVO ASSAY FOR VITELLOGENIN INDUCTION IN FISH EXPOSED TO SYNTHETIC AND XENOESTROGENS.
• FIELD VALIDATION OF VITELLOGENIN INDUCTION IN FERAL MALE FISH AS AN INDICATOR OF EXPOSURE TO ESTROGENIC COMPOUNDS.
• LABORATORY ASSESSMENT OF VARIABILITY ASSOCIATED WITH MEASURMENTS OF VITELLOGENIN AND BRAIN AROMATASE ACTIVITY IN FISH3. Project Focus: ECOLOGICAL EFFECTS, EXPOSURE ASSESSMENT
• An in vivo model for detection of reproductive effects of endocrine disruptors
• Metabolic Androgenization of Invertebrates by Endocrine-Disrupting Chemicals
• Endocrine Disruption in the Marine Environment (EDMAR)
• Effects of endocrine-disrupting chemicals on reproductive function of fish
• Effects on reproductive disorders in fish
• In vitro analysis of endocrine activity of environmental samples and of mixtures of chemicals
• The effect of oestrogenic compounds on the life history of the pond snail Lymnaea stagnalis
• TOXICOLOGICAL EVALUATION OF THE REPRODUCTIVE AND IMMUNE SYSTEMS OF THE ST. LAWRENCE RIVER BELUGA WHALES EXPOSED TO ENDOCRINE DISRUPTORS
• Bioindicators of exposure to and effects of xenoestrogens in the marine environment
• Effects of environmental endocrine disruptors in the tropical fish, tilapia (oreochromis mossambicus)

• Development of a new in vitro system for detection of estrogenic activity of environmental chemicals
• Materials Flow Analysis of major Endocrine Disrupting Industrial Chemicals (Bisphenol A; Dibutylphthalate/Benzylbutylphthalate; Nonylphenol/Alkylphenolethoxylates)
• Response related analytics of environmental compounds with receptor assays
• Estrogenic and Toxicological effects of environmental pollutants in Fish
• Substances with endocrine disrupting potential in various environmental compartments.
• Identification, exposure assessment and characterization of risks by xenestrogens and other endocrin effective agents present in German freshwater and marine environments: Field and laboratory studies
• Detection and fate of endocrine disruptors in the environment
• Exposure and ecological effects of hazardous substances and drugs in surface waters
• biomarkers for estrogen-active compounds
• Alkylphenols in agricultural ecosystems
• Human exposure to phyto- and xenoestrogens using selected chemicals as examples
• The influence of xenoestrogens on Sertoli-cell number.
• Environmental Exposure Assessment of Endocrine Disrupters in Sewage Treatment Works and River Water
• Biochemical response of the mudpuppy (Necturus maculosus) to the pollution of
• Ocurrence of nonylphenol and nonylphenol polyethoxylates in Canadian aquatic
• Assessment of Trace Organic Contaminants in Sediments and Water from the
• OCCURRENCE OF AN ENVIRONMENTAL ESTROGEN (4-NONYLPHENOL) IN
• Assessment of Contaminants Associated with Bed Sediments in Canadas Fraser
• Effects of environmental contaminants on the response of a suite of biomarkers
• Release and fate of estrogenic and (anti)androgenic substances to the aquatic environment
• ESTABLISHMENT OF AN IN VIVO EMBRYONIC SYSTEM FOR THE ASSESSMENT OF MOLECULAR AND CELLULAR EFFECTS OF ENDOCRINE MODULATION COMPOUNDS
• REPRODUCTIVE TOXICOLOGY IN TERRESTRIAL MAMMALS OF SIGNIFICANCE TO WESTERN CANADIAN AGRICULTURE
• MOLECULAR APPROACHES TO TOXICITY BY TMPP.
• Critical Stages in Sublethal Exposure to EDCs in a Quail Model System
• DETERMINATION OF THE ENDOCRINE DISRUPTEORS, BISPHENOL-A AND NONYL PHENOL, MIGRATING TO FOODS AS THE RESULT OF THEIR USE AS APPROVED INDIRECT ADDITIVE CHEMICALS IN FOOD PACKAGING
• Detection and Identification of Estrogenic/antiestrogenic Compounds in the Marine Environment
• Pilot Field Study to Refine the Measurement and Methods of Fifteen Suspect Endocrine Disrupting Compounds in the Neuse River Basin
• Use of a Hybrid Multimedia Compartmental Model to Assist Field Monitoring Project Design for Endocrine Disruptor Detection, Media Concentration, Exposure Model Development and/or Model Confirmation and to Support Fate and Transport Endocrine Disruptor Exposure (EDE) Research
• Analyssi of residue levels of endocrine disruptor in human umbilical cords & fetus
• Endocrine disruptors
• Release and fate of estrogenic and (anti)androgenic substances into theaquatic environment Release and fate of estrogenic and (anti)androgenic substances into theaquatic environment
• Xenoestrogen effects during premeiotic stages of spermatogenesis: Development of an invitro test system and molecular markers of action
• Amphibians as a model to study endocrine disruptors
• Investigating the Spread and Causes of Amphibian Declines in Tropical America
• NATIONAL INVESTIGATION INTO THE OCCURRENCE AND EFFECTS OF ESTROGENIC-ACTIVE COMPOUNDS IN THE AQUATIC ENVIRONMENT
• Studies on the EDCs in food containers, elution of the EDCs to the food, and assessment method of food contamination.
• Development of a high-sensitivity analysis method and its application to monitoring of chemical concentrations in the environment.
• Development of high-sensitivity analysis methods of endocrine disrupting chemicals
• Early life stage exposure to environmental oesrtogens in relation to reproductive and developmental ecology of model and commercially important species
• The influence of environmental oestrogens on vitellogenesis in crustaceans
• Effects of endocrine disruptors on fish
• Effects of endocrine disruptors on fish
• Vitellogenin as a biomarker in screening chemicals for estrogenic effects: Relationship between vitellogenin induction, reproduction and sexual development.