1. Sponsor Organization: NIH/NCI

2. Project Title: 51019-000 FOLLOW UP OF DES EXPOSED COHORTS

3. Project Focus:

• Project Primary Focus: Human Health Effects
• Project Secondary Focus: Exposure Assessment

4. Description:

The primary objective of this contract shall be to provide support services for the Environmental Epidemiology Branch (EEB), Epidemiology & Biostatistics Program (EBP), Division of Cancer Etiology (DCE), National Cancer Institute (NCI), by continuing the follow-up of a cohort of DES-exposed individuals for the estimation of long-term cancer risk. In addition, specific sub-studies of non-cancer endpoints, using the resource of the combined cohort, shall be designed and conducted. The recommendations of the 1 992 NIH workshop on DES shall be relied upon to form priorities for specific studies. A "Steering Committee" shall be formed to guide and coordinate future research efforts in the DES-exposed and comparison cohorts.

5. References:

6. Inventory Category:

• Primary: Measure
• Secondary: Models

7. Inventory Subcategory:

• Primary: Exposure Follow Up
• Secondary:
  • Exposure And Risk Models

8. Keywords for Experimental System/Species:

• Species:
  • Human
• Study Type:
  • Epidemiology
• Fate and Transport:

9. Keywords for Experimental Endpoints:

• Health Effect:
  • Carcinogenesis
• Hormonal Measures:
• Level Of Study:
  • Epidemiology
• Chemistry Metabolism:
• Life Stage:
  • Female
• Risk Assessment:

10. Chemical Agents:

• Diethylstilbestrol

11. Performing Institution:

• DARTMOUTH COLLEGE

12. Contact:

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