1. Sponsor Organization: NIH/NIEHS

2. Project Title: 00040-33 TOXICOLOGY OF ENVIRONMENTAL CHEMICALS

3. Project Focus:

• Project Primary Focus: Human Health Effects
• Project Secondary Focus: Exposure Assessment

4. Description:

Research is directed toward understanding the mechanisms of toxicity of selected bioenvironmental chemicals, especially halocarbons, a major class of bioenvironmental contaminants that ultimately pose human health hazards. With an interdisciplinary basis for the research, the main research objectives include: (1) Structural identification and quantitation by mass spectrometry of certain electrophilic bioenvironmental pollutants,especially aromatic hydrocarbons, that utilizes recent findings about mechanisms of fragmentation which are common between photochemical and mass spectral events for polyhaloarenes. (2) Elucidation of the mechanistic pathways for the photochemical transformations of environmentally significant polyhaloarenes and the application of the mechanistic conclusions to the development of an understanding of the transformation and creation of toxic components in the environment and to the development of new methods of toxic waste disposal. (3) Investigation of the biochemical and molecular mechanisms underlying alterations in T cell activation induced by the aromatic halocarbon 2,3,7,8--tetrachlorodibenzo--p--dioxin and the elucidation of the relationship between altered T cell activation and altered immune function. (4) Determination, definition, and elucidation of the cellular and in vivo events that are important in the toxicity of glutathione conjugates of saturated aliphatic halocarbons and bisulfites and the corresponding protein thiol adducts.

5. References:

6. Inventory Category:

• Primary: Models
• Secondary:

7. Inventory Subcategory:

• Primary: Multidisciplinary Research
• Secondary:

8. Keywords for Experimental System/Species:

• Species:
  • Human
• Study Type:
  • In Vivo
  • Laboratory Study
• Fate and Transport:
  • Environmental Fate And Transport

9. Keywords for Experimental Endpoints:

• Health Effect:
  • Immunology
• Hormonal Measures:
• Level Of Study:
  • Biochemistry
• Chemistry Metabolism:
  • Toxicokinetics
  • Exposure Monitoring
• Life Stage:
• Risk Assessment:

10. Chemical Agents:

• Pcdds
• Bisulfites

11. Performing Institution:

• OREGON STATE UNIVERSITY

12. Contact:

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