1. Sponsor Organization: NIH/NIEHS

2. Project Title: 04090-10 CALCIUM-SURROGATE ACTIONS OF LEAD IONS IN SECRETION

3. Project Focus:

• Project Primary Focus: Human Health Effects
• Project Secondary Focus:

4. Description:

Disruption of neurotransmitter and hormone release is a likely factor in neurobehavioral, neuroendocrine, and endocrine disturbances associated with low-level lead (Pb2+) toxicity. The overall goal of this research is to assess the role of pb2+ interactions with calcium-signal transduction mechanisms, with focus on the Ca2+-dependent secretion of neurotransmitters and hormones.

5. References:

6. Inventory Category:

• Primary: Models
• Secondary:

7. Inventory Subcategory:

• Primary: Basic Research
• Secondary:

8. Keywords for Experimental System/Species:

• Species:
• Study Type:
  • In Vitro
  • Laboratory Study
• Fate and Transport:

9. Keywords for Experimental Endpoints:

• Health Effect:
  • Neurological
  • Molecular, Signal Transduction
• Hormonal Measures:
• Level Of Study:
• Chemistry Metabolism:
• Life Stage:
• Risk Assessment:

10. Chemical Agents:

• Lead

11. Performing Institution:

• UNIVERSITY OF CINCINNATI

12. Contact:

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