1. Sponsor Organization: NIH/NIEHS

2. Project Title: 04214-11 ENDOCRINE EFFECTS OF REPRODUCTIVE TOXINS IN FEMALE FISH

3. Project Focus:

• Project Primary Focus: Ecological Effects
• Project Secondary Focus:

4. Description:

The long term goals of this research are to identify the common sites and mechanisms of chemical interference with reproductive endocrine function in vertebrates, using two teleosts, Atlantic croaker and spotted seatrout (Cynoscion nebulosus), as models. The overall aims of this continuation proposal are to determine the extent and nature of xenobiotic interactions with a representative of steroid membrane receptors, the well characterized plasma membrane receptor in spotted seatrout ovaries for the maturation-inducing steroid, 17a, 20B, 21-trihydroxy- 4- pregnen-3-one (20B-S), which regulates final oocyte maturation by a nongenomic mechanism.

5. References:

6. Inventory Category:

• Primary: Models
• Secondary:

7. Inventory Subcategory:

• Primary: Basic Research
• Secondary:

8. Keywords for Experimental System/Species:

• Species:
  • Fish
• Study Type:
  • In Vitro
  • In Vivo
• Fate and Transport:

9. Keywords for Experimental Endpoints:

• Health Effect:
  • Reproductive
• Hormonal Measures:
  • Hormonal Measures,
• Level Of Study:
• Chemistry Metabolism:
  • Xenobiotic Metabolism
• Life Stage:
  • Female
• Risk Assessment:

10. Chemical Agents:

• Metals
• Lead
• Cadmium, Arochlor 1254, Clomiphene, Chlordecone

11. Performing Institution:

• UNIVERSITY OF TEXAS AUSTIN

12. Contact:

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