1. Sponsor Organization: NIH/NIEHS

2. Project Title: 04913-08 MULTIDISCIPLINARY STUDY OF POLYCHLORINATED BIPHENYLS (PCBS) AT AKWESASNE

3. Project Focus:

• Project Primary Focus: Exposure Assessment
• Project Secondary Focus:

4. Description:

This is a study of a Native American population iving near a Superfund site and exposed to polychlorinated biphenyls (PCBs) and to a lesser extent, polychlorinated dibenzofurans (PCDFs) and polynuclear aromatic hydrocarbons (PAGs) thru consumption of local fish and wildlife. We have shown in this population that there was a clear correlation between fish consumption and levels of PCBs in breast milk, although this relationship has decreased as the population has heeded advisories against fish consumption. We ae presently studying the physical growth and cognitive development of older children as well as physical and mental health of adults. These studies of the human population are based on previous and concurrent study in animal systems designed to explore the effects of these xenobiotics on neuronal, hormonal and immune systems. The specific hypotheses to be tested are that different congeners have different biologic effects, that congeners of these xenobiotics function as estrogenic or anti-estrogenic agents, interfere with normal thyroid faction, disrupt normal regulation of brain levels of critical neurotransmitters such as dopamine, and interfere with both normal growth and development and cognitive function.

5. References:

6. Inventory Category:

• Primary: Methods
• Secondary:

7. Inventory Subcategory:

• Primary: Multidisciplinary Research
• Secondary:

8. Keywords for Experimental System/Species:

• Species:
  • Human
• Study Type:
  • Field Study
• Fate and Transport:

9. Keywords for Experimental Endpoints:

• Health Effect:
  • Reproductive
  • Growth
• Hormonal Measures:
• Level Of Study:
  • Epidemiology
• Chemistry Metabolism:
• Life Stage:
• Risk Assessment:

10. Chemical Agents:

• Pcbs
• Pcdfs
• Pags

11. Performing Institution:

• STATE UNIVERSITY OF NEW YORK AT ALBANY

12. Contact:

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