1. Sponsor Organization: NIH/NIEHS

2. Project Title: 05033-13 ENVIRONMENTAL/INDUSTRIAL TOXICANTS AND TESTICULAR INJURY

3. Project Focus:

• Project Primary Focus: Human Health Effects
• Project Secondary Focus:

4. Description:

This study examines the hyposthesis that a new testicular toxicsnt, 2,5-hexanedione, alters microtubule dynamics compromising Sertoli cell microtubule-dependent organelle transport resulting in a failure of seminiferous tubule fluid formation and germ cell necrosis. This hypothesis will be tested by the following Specific Aims: 1) use video microscopy to compare the movement of 2,5-hexanedione-treated and control

5. References:

6. Inventory Category:

• Primary: Models
• Secondary:

7. Inventory Subcategory:

• Primary: Basic Research
• Secondary:

8. Keywords for Experimental System/Species:

• Species:
• Study Type:
  • In Vitro
  • Laboratory Study
• Fate and Transport:

9. Keywords for Experimental Endpoints:

• Health Effect:
• Hormonal Measures:
• Level Of Study:
• Chemistry Metabolism:
• Life Stage:
  • Male
  • Reproductive
• Risk Assessment:

10. Chemical Agents:

• 2, 5-Hexanedione

11. Performing Institution:

• BROWN UNIVERSITY

12. Contact:

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