1. Sponsor Organization: NIH/NIEHS

2. Project Title: 05495-06 IMMUNOTOXICITY OF POLYCYCLIC AROMATIC HYDROCARBONS

3. Project Focus:

• Project Primary Focus: Human Health Effects
• Project Secondary Focus:

4. Description:

This project examines themechanisms by which polycyclic aromatic hydrocarbons (PAHs) alter Ca2+-dependent antigen and growth factor signaling pathways in human lymphoid cells leading to immunotoxicity (immunosuppression and cell death) and human proto-oncogene activation.

5. References:

6. Inventory Category:

• Primary: Models
• Secondary:

7. Inventory Subcategory:

• Primary: Basic Research
• Secondary:

8. Keywords for Experimental System/Species:

• Species:
  • Human
• Study Type:
  • In Vitro
  • In Vivo
  • Laboratory Study
• Fate and Transport:

9. Keywords for Experimental Endpoints:

• Health Effect:
  • Immunology
• Hormonal Measures:
• Level Of Study:
• Chemistry Metabolism:
• Life Stage:
• Risk Assessment:

10. Chemical Agents:

• Pahs

11. Performing Institution:

• UNIVERSITY OF NEW MEXICO ALBUQUERQUE

12. Contact:

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