1. Sponsor Organization: NIH/NIEHS

2. Project Title: 07375-03 HEALTH EFFECTS OF CHLORINATED COMPOUNDS

3. Project Focus:

• Project Primary Focus: Human Health Effects
• Project Secondary Focus: Ecological Effects

4. Description:

The program project consists of seven individual projects whose focus on improving sensitivity for detecting adverse effects of chlorinated compounds involves either: 1) study of mechanisms and dose-response relationships for health effects most likely to occur with environmentally-relevant exposures, viz. immune effects, reproductive/developmental effects, and cancer; 2) study of factors which lead to increased sensitivity (vulnerability) toxicity; 3) sensitive methods for detecting toxicity; or 4) sensitive methods for detecting/measuring contaminants in biological systems. The four individual projects are: Endocrine- Disrupting Effects of Chlorinated Hydrocarbons on Wildlife; Placental-Uterine Effects of Chlorinated Hydrocarbons; Dichloroacetate Kinetics, Metabolism and Human Toxicology; and Bioavailability of Superfund Chemicals. Three of the research projects are primarily or entirely biomedical in orientation, while one is primarily or entirely non-biomedical. Proposed research involves studies of toxicity in species ranging from fish and alligators to rats and mice to humans. These projects offer an integrated approach to advancing knowledge regarding the human and environmental impact of chlorinated organic contaminants.

5. References:

6. Inventory Category:

• Primary: Models
• Secondary:

7. Inventory Subcategory:

• Primary: Basic Research
• Secondary:

8. Keywords for Experimental System/Species:

• Species:
  • Fish
  • Reptil
  • Mammal
  • Human
  • Rat, Mouse
• Study Type:
  • Field Study
• Fate and Transport:

9. Keywords for Experimental Endpoints:

• Health Effect:
  • Carcinogenesis
  • Reproductive
• Hormonal Measures:
• Level Of Study:
• Chemistry Metabolism:
• Life Stage:
• Risk Assessment:

10. Chemical Agents:

• Organochlorines

11. Performing Institution:

• UNIVERSITY OF FLORIDA

12. Contact:

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