1. Sponsor Organization: NIH/NIEHS

2. Project Title: 07384-03 LEAD AND ORGANOCHLORINES IN NEW YORK CITY

3. Project Focus:

• Project Primary Focus: Human Health Effects
• Project Secondary Focus:

4. Description:

This Project will examine: (1) The current sources of lead in the Hudson River and New York Harbor; (2) The mobilization of lead during pregnancy from endogenous skeletal sources in urban women; (3) The mobilization of lead during surgically induced menopause in urban women and its possible association with neuropsychological dysfunction; (4) The sources and distribution of chlorinated hydrocarbons in the Hudson River and New York Harbor; (5) The possibility that chlorinated hydrocarbons in New York harbor sediments exhibit hormonal activity; (6) The possibility that PCBs or PCB-contaminated harbor sediments may enhance carcinogen metabolism in normal human mammary cells in vitro.

5. References:

6. Inventory Category:

• Primary: Methods
• Secondary:

7. Inventory Subcategory:

• Primary: Multidisciplinary Research
• Secondary:
  • Hazard Identification

8. Keywords for Experimental System/Species:

• Species:
  • Human
• Study Type:
  • In Vitro
  • Field Study
  • Laboratory Study
• Fate and Transport:

9. Keywords for Experimental Endpoints:

• Health Effect:
  • Carcinogenesis
  • Neurological
• Hormonal Measures:
• Level Of Study:
• Chemistry Metabolism:
  • Exposure Monitoring
• Life Stage:
• Risk Assessment:

10. Chemical Agents:

• Lead
• Organochlorines
• Pcbs
• Ddt,

11. Performing Institution:

• MOUNT SINAI SCHOOL OF MEDICINE

12. Contact:

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