1. Sponsor Organization: NIH/NIEHS

2. Project Title: 03719-13 CONTROL OF GENE EXPRESSION BY DIOXIN

3. Project Focus:

• Project Primary Focus: Human Health Effects
• Project Secondary Focus:

4. Description:

The aromatic hydrocarbon (Ah) receptor is an intracellular protein that binds and mediates the biological effects of the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). The liganded Ah receptor heterodimerizes with a second protein (known as Arnt) in activating CYP1A1 gene transcription in mouse hepatoma cells. The proposed studies involve: (1) analyses of the functional domains of the Ah receptor, (2) identification of additional protein partners for the receptor, and (3) characterization of receptor function in the absee of TCDD. The experiments utilize a variety of techniques in molecular biology, cellular biology, and genetics. The studies are designed to generate new insights into the mechanism of TCDD action; the findings may help in assessing the risk that dioxin poses to human health.

5. References:

6. Inventory Category:

• Primary: Models
• Secondary:

7. Inventory Subcategory:

• Primary: Basic Research
• Secondary:

8. Keywords for Experimental System/Species:

• Species:
  • Mammal
• Study Type:
• Fate and Transport:

9. Keywords for Experimental Endpoints:

• Health Effect:
• Hormonal Measures:
  • Ah Receptor. Molecular
• Level Of Study:
• Chemistry Metabolism:
• Life Stage:
• Risk Assessment:
  • Risk Assessment

10. Chemical Agents:

• Dioxins

11. Performing Institution:

• STANFORD UNIVERSITY

12. Contact:

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