1. Sponsor Organization: NIH/NIEHS

2. Project Title: 04917-09 PROCEDURES TO ASSESS THE HAZARD OF A SUPERFUND SITE

3. Project Focus:

• Project Primary Focus: Exposure Assessment
• Project Secondary Focus:

4. Description:

The major focus of this Superfund Program remains the development and validation of in vivo and in vitro bioassays which can be used for risk assessment of oily and wood-preserving wastes. One goal has been to develop and validate a variety of diverse chemical class-specific bioassays that can be utilized for risk assessment of complex toxic mixtures. To achieve this aim, the project has utilized both model compounds and reconstituted mixtures to determine relative potencies of individual congeners and the additive or non-additive interactions which are observed for mixtures. In some studies, the toxic and/or biochemical effects of mixtures obtained from specific hazardous waste sites have also been determined. Progress is reported in determining relative potencies or toxic equivaley factors (TEFs) for some of the most toxic individual compounds that have been identified, and this approach is now being utilized for risk assessment by regulatory agencies worldwide.

5. References:

6. Inventory Category:

• Primary: Measure
• Secondary:

7. Inventory Subcategory:

• Primary: Hazard Identification
• Secondary:
  • Mixtures

8. Keywords for Experimental System/Species:

• Species:
• Study Type:
  • In Vitro
  • In Vivo
• Fate and Transport:

9. Keywords for Experimental Endpoints:

• Health Effect:
• Hormonal Measures:
• Level Of Study:
• Chemistry Metabolism:
• Life Stage:
• Risk Assessment:
  • Risk Assessment

10. Chemical Agents:

• Oily And Wood Preserving Wastes

11. Performing Institution:

• TEXAS A&M UNIVERSITY HEALTH SCIEE CTR

12. Contact:

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