1. Sponsor Organization: NIH/NIEHS

2. Project Title: 05679-03 DIOXIN ACTION-- NEW PROTEIN PARTNERS FOR THE AH RECEPTOR

3. Project Focus:

• Project Primary Focus: Human Health Effects
• Project Secondary Focus:

4. Description:

2,3,7,8-Tetrachlorodibenzo-p-dioxin is the prototype of a group of halogenated aromatic hydrocarbons (HAH) that are widespread and persistent environmental pollutants. Animals exposed to TCDD exhibit a range of toxic effects including alterations in metabolic pathways, immunological changes, teratogenic effects, and neoplasia. Epidemiological studies demonstrate that exposure to TCDD causes skin lesions and possibly ireased risks for some forms of cancer in human population. Ah (Aromatic hydrocarbon) receptor (AhR) is a bHLH transcription factor which, together with other proteins, mediates the biological effects of TCDD. The overall goal of the proposed project is to identify new protein partners for the Ah receptor. The specific aims of the study are: (1) identification of the receptor's functional domains, with emphasis on domains responsible for binding HLH protein(s), transcription activation, and transcription inhibition; (2) identification, cloning, and characterization of proteins (other than Arnt) that interact with and modulate the functions of the Ah receptor. This research will provide a better understanding of the mechanism by which TCDD elicits its biological effects in vivo. This knowledge may help to resolve uertainty in assessing the risk that TCDD poses to human health.

5. References:

6. Inventory Category:

• Primary: Models
• Secondary:

7. Inventory Subcategory:

• Primary: Basic Research
• Secondary:

8. Keywords for Experimental System/Species:

• Species:
• Study Type:
  • Laboratory Study
• Fate and Transport:

9. Keywords for Experimental Endpoints:

• Health Effect:
• Hormonal Measures:
  • Ah Receptor, Molecular
• Level Of Study:
• Chemistry Metabolism:
• Life Stage:
• Risk Assessment:

10. Chemical Agents:

• Dioxins

11. Performing Institution:

• STANFORD UNIVERSITY

12. Contact:

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