1. Sponsor Organization: NIH/NIEHS

2. Project Title: 05950-06 SUPERFUND BASIC RESEARCH

3. Project Focus:

• Project Primary Focus: Human Health Effects
• Project Secondary Focus:

4. Description:

The Cornell Superfund Basic Research and Education Program (SBRBP) studies the bioavailability and impact of hazardous substaes in human health and ecological risk, especially as related to exposure, neurological and immunological effects, and remediation of sites containing polychlorinated biphenyls (PCBs), polycyclic aromatic hydrocarbons (PAHs), and heavy metals such as lead (Pb). This project examines biological responses (developmental, immunologic and neurologic/behavioral) in which exposure can be integrated across diverse species, and biodegradation studies and chemodynamics can be integrated via interactive modeling. In addition to the core activities (administration, lab technical services, and training), the program proposes three basic biomedical project (dogs as sentinels for immunologic threats from PCBs, rats and chickens as responding to chelation therapy following Pb exposure, and rats responding to the same stressor, but evaluated with respect to cognitive deficits). A fourth basic biomedical project (immunobiosensors) will link some of the field work to both results in lab animals and wildlife and to success in describing field exposures. The companion notion is that bioavailability may be reflected in biodegradation patterns and successfully modeled as a statistical process of chemodynamic interactions. Three projects propose to examine sequestration as a matter of aging, the role of exopolymers to alter distributions of organics and then inorganics, and the development of visualization methods to characterize microscale forces and locations.

5. References:

6. Inventory Category:

• Primary: Methods
• Secondary:

7. Inventory Subcategory:

• Primary: Exposure and Risk Models
• Secondary:
  • Sentinel Species

8. Keywords for Experimental System/Species:

• Species:
  • Avian
  • Mammal
  • Dogs, Rats
• Study Type:
  • Field Study
  • Laboratory Study
• Fate and Transport:
  • Environmental Fate And Transport

9. Keywords for Experimental Endpoints:

• Health Effect:
  • Neurological
  • Immunology
  • Reproductive
• Hormonal Measures:
• Level Of Study:
• Chemistry Metabolism:
  • Exposure Monitoring
• Life Stage:
• Risk Assessment:
  • Risk Assessment

10. Chemical Agents:

• Lead
• Pahs
• Pcbs

11. Performing Institution:

• CORNELL UNIVERSITY ITHACA

12. Contact:

Edit (password needed)