1. Sponsor Organization: NIH/NIEHS

2. Project Title: 06065-05 IMMUNITY IN CHILDREN WITH EXPOSURE TO ENVIRONMENTAL LEAD

3. Project Focus:

• Project Primary Focus: Human Health Effects
• Project Secondary Focus:

4. Description:

The proposed study addresses the impact of environmental lead on the developing immune system of young children. In animal model systems, lead levels far below those necessary for overt toxicity are found to be immunosuppressive. It is difficult to extrapolate these data to human systems. A study population of urban children (9 months to 6 years of age) with blood levels greater than 10 micrograms/1OO ml has been identified in the Springfield-Greene County area of Missouri through participation in local WIC (Women, Infants, and Children) and Lead Poisoning Prevention programs. This pool of children, with appropriately matched controls from the same programs, have offered an ideal opportunity to begin an assessment of possible correlations between blood lead concentrations and various immune system parameters. Preliminary studies have resulted in the selection of a number of specific assays proposed to assess possible effects of lead on cell numbers (counts of WBC types, including classes and subclasses of lymphocytes); effects on B cell function (serum Ig concentrations including IgE; cell surface class II density; cell surface density of the activation antigens CD71 (transferrin Rc) and B7]; effects on T cell function (proliferative response to IL-2; cell surface density of the activation antigens CD25 (IL-2 Rc), CD71, and CD28); and effects on concerted immune responses (specific antibody titers to vaccines; proliferative responses to antigens; release of soluble cytokine receptors (CD25 and CD27); frequeies of infections and allergies). Preliminary data have also allowed a determination of appropriate sample size and generation of essential control data for these selected parameters.

5. References:

6. Inventory Category:

• Primary: Measure
• Secondary:

7. Inventory Subcategory:

• Primary: Exposure and Risk Models
• Secondary:

8. Keywords for Experimental System/Species:

• Species:
  • Human
• Study Type:
  • Field Study
• Fate and Transport:

9. Keywords for Experimental Endpoints:

• Health Effect:
• Hormonal Measures:
• Level Of Study:
• Chemistry Metabolism:
  • Exposure Monitoring
• Life Stage:
• Risk Assessment:

10. Chemical Agents:

• Lead

11. Performing Institution:

• UNIVERSITY OF MISSOURI ROLLA

12. Contact:

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