1. Sponsor Organization: NIH/NIEHS

2. Project Title: 44003-20 EPIDEMIOLOGIC STUDY OF REPRODUCTIVE OUTCOMES AND ENVIRONMENTAL EXPOSURES

3. Project Focus:

• Project Primary Focus: Human Health Effects
• Project Secondary Focus:

4. Description:

This project examines environmental effects on human reproduction, together with the basic biology that underlies such effects. In a major study of adults who were prenatally exposed to DES, we were unable to confirm a variety of health effects seen in animal studies and reported anecdotally in humans. DES sons were found to have the same fertility as unexposed sons. DES daughters showed no evidence of premature menopause. Finally, we found no evidence of higher rates of infection or autimmune disease among DES offspring. This suggests that humans may be less vulnerable to adverse effects of prenatal estrogens than has been hypothesized.

5. References:

6. Inventory Category:

• Primary: Measure
• Secondary:

7. Inventory Subcategory:

• Primary: Hazard Identification
• Secondary:

8. Keywords for Experimental System/Species:

• Species:
  • Human
• Study Type:
• Fate and Transport:

9. Keywords for Experimental Endpoints:

• Health Effect:
  • Immunology
  • Reproductive
• Hormonal Measures:
• Level Of Study:
• Chemistry Metabolism:
• Life Stage:
  • Female
  • Male
• Risk Assessment:

10. Chemical Agents:

• Diethylstilbestrol

11. Performing Institution:

• NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

12. Contact:

Edit (password needed)