1. Sponsor Organization: NIH/NIEHS

2. Project Title: 47002-11 BIOLOGICAL EFFECTS OF PLANT ESTROGENS IN POSTMENOPAUSAL WOMEN

3. Project Focus:

• Project Primary Focus: Human Health Effects
• Project Secondary Focus:

4. Description:

Exposure to highly estrogenic substaes can disrupt reproduction and increase cancer risk, as well as influence bone metabolism and cardiovascular health. Chemicals that are weakly estrogenic are widespread in the environment, including several pesticides. Health effects of these environmental estrogens are not known. This project is designed to determine whether a test-case exposure to environmental estrogens, i.e., exposure to dietary soybeans (rich in plant estrogens) has the expected estrogenic effects. The experimental study compares women who were randomized to a soy-diet group with women who ate normally.

5. References:

6. Inventory Category:

• Primary: Measure
• Secondary:

7. Inventory Subcategory:

• Primary: Exposure and Risk Models
• Secondary:

8. Keywords for Experimental System/Species:

• Species:
  • Human
• Study Type:
  • Field Study
• Fate and Transport:

9. Keywords for Experimental Endpoints:

• Health Effect:
  • Carcinogenesis
• Hormonal Measures:
• Level Of Study:
• Chemistry Metabolism:
  • Exposure Monitoring
• Life Stage:
• Risk Assessment:

10. Chemical Agents:

• Phytoestrogens

11. Performing Institution:

• NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

12. Contact:

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