Exposure Assessment
Development of high-sensitivity analysis methods of endocrine disrupting chemicals
Development of a high-sensitivity analysis method and its application to monitoring of chemical concentrations in the environment.
Analyssi of residue levels of endocrine disruptor in human umbilical cords & fetus
Studies on the EDCs in food containers, elution of the EDCs to the food, and assessment method of food contamination.
Studies on the EDCs in food containers, elution of the EDCs to the food, and assessment method of food contamination.
Development of immunochemical measurement system for triazines in the environment.
Investigations of the actual conditions of endocrine disrupting chemicals on testicular function.
Effects of endocrine disruptors on mammalian gonads and gametes
Application in vivo of non-destructive multielement anaylsis method for endocrine disrupting chemicals.
Dissection of molecular mechanisms underlying the biological effects of endocrine disruptors
Developement of Immunological method of triazines in environment.
Studies for elucidating effects of endocrine disruptors on human spermatogenesis
Human Health Effects
Development and validation of high through put screening using human cell reporter gene assay.
OECD validation studies
OECD validation studies-extended
Assessment of anti-androgen activity in Hershberger assay using indices on cell turnover of prostatic ventral lobe.
A novel in vivo screening method on ECDs, an application of alpha2u-globulin to EDC screening.
A study on the development of a new in vitro assay targeted on the possible membrane-receptor mediated EDC effects.
Combined effect of representative EDCs in uterotrophic, hershberger and modified one generation assays (contract study)
Effects of endocrine disrupting chemicals on mouse gonad differentiation, spermgenesis and oogeuesis
Development of in vitro system exhibiting human metabolic enzyme systems that modify the EDC molecules
Development of screening system on the hormone receptor-mediated EDCs by yeast two-hybrid system.
Studies on the semen quality in general population of Japan
Effects of endocrine disrupting chemicals on central neuronal system and germ cells
Effects of endocrine disrupting chemicals on neuronal stem-cell differentiation
Effects of fetal and neonatal exposure to EDCs on the structural alterations of Hypothalamic nuclei and the influence on the reproduction.
A study on the effect of Phthalates on reproduction.
Basic studies on the OECD GL407 as an EDC assay
Effects of endocrine disrupting chemicals on the thyroid carcinogenesis.
Elucidation of toxicity mechanisms of endocrine disruptors that bind sex hormone receptors
Developmental effects of endocrine disruptors on mouse reproductive organs
Study of the mechanism of endocrine disruptors on gene expression of C. elegans
Effects of EDCs on the uterine carcinogenesis model
Mechanistic studies on the perturbation of organogenesis caused by endocrine disruptors
3D-QSAR of EDCs, by computer simulation system using the docking method.
Biological and molecular aspects of EDCs with a special reference to 3D-QSAR analysis.
Application of Surface Plasmon Resonanse method to high through put screening
Effects of endocrine disruptors on chemokine production.
Cross-talk of signal transduction of endocrine disruptors between arylhydrocarbone and steroid hormone receptors
Development of a EDC screening system using sex-differentiation related gene expression in chick embryo
Mechanism of adverse effects from endocrine disruptors
Development of screening method of EDCs by the rodent intrauterine exposure models.
Effects of endocrine disrupting chemicals on immune system
Effects of estrogenic compounds on early development of the chick embryo
The study on the effects of endocrine disrupting chemicals on steroid hormone receptors
Aryl hydrocarbons as endocrine disruptors, a method development study.
Development of EDC screening method using cell line transfected with human estrogen receptor gene.
Analysis of testis-weight and spermatogenesis in Japanese men by using analytical data of necropsy
Development of intrauterine exposure screening rodent model
Refinement of Yeast Two-hybrid system on EDC screening
Androgen receptor reporter gene assay system using a human cell line.
A study on the effect of untrauterine exposure on the reproduction of the next generation (F2).
Analysis of Polyglutamine neurotxicity by endocrine disrupting chemicals a as risk factor
Analyses on the effect of ECDs on the estrogen metabolism and possible application to screening.
Mechanism of possible human health effect of endocrine disrupting chemicals
Effect of endocrine disruptors on highly integrated systems.
Carcinogenic effect of endocrine disrupting chemicals
Sex steroid hormone metabolism: enzyme and receptor expression in human tissues
Development of detection system for endocrine disruptors with special reference to its mechanisms
A study on the validation of high through put systems using reporter gene assay system and surface plasmon resonance method
Molecular mechanism of receptor-mediated endocrine disrupting chemicals
Development of effective bioassay system for endocrine dirsuptors in the workplace.
The effects of hormones and EDCs on nueronal network
Development of bioassay system of EDC effects on fish.