Global Endocrine Disruptor Research Project Level Inventory
Japan by Primary Focus
- In situ monitoring of endocrine disruption using marine fish-2
- Development of bioassay system of EDC effects on fish.
- Study on endocrine disruption in long-lived wildlife-4
- Study on endocrine disruption in long-lived wildlife-3
- Informatics of the EDCs
- Study on endocrine disruption in long-lived wildlife-2
- Study on endocrine disruption in long-lived wildlife
- Research on reproductive biology of wild birds.
- Field study on endocrine disruption and polution-Decline in molluscs
- Establishment of biological methods to monitor endocrine disruptions in aquatic wildlife
- In situ monitoring of endocrine disruption using marine fish
- Effects endocrine disruptors on fish reproduction
- Studies on induction mechanism of imposex in gastropods
- Effects on reproductive disorders in fish
Exposure Assessment
- Development of high-sensitivity analysis methods of endocrine disrupting chemicals
- Development of a high-sensitivity analysis method and its application to monitoring of chemical concentrations in the environment.
- Analyssi of residue levels of endocrine disruptor in human umbilical cords & fetus
- Studies on the EDCs in food containers, elution of the EDCs to the food, and assessment method of food contamination.
- Studies on the EDCs in food containers, elution of the EDCs to the food, and assessment method of food contamination.
- Development of immunochemical measurement system for triazines in the environment.
- Investigations of the actual conditions of endocrine disrupting chemicals on testicular function.
- Effects of endocrine disruptors on mammalian gonads and gametes
- Application in vivo of non-destructive multielement anaylsis method for endocrine disrupting chemicals.
- Dissection of molecular mechanisms underlying the biological effects of endocrine disruptors
- Developement of Immunological method of triazines in environment.
- Studies for elucidating effects of endocrine disruptors on human spermatogenesis
Human Health Effects
- Development and validation of high through put screening using human cell reporter gene assay.
- OECD validation studies
- OECD validation studies-extended
- Assessment of anti-androgen activity in Hershberger assay using indices on cell turnover of prostatic ventral lobe.
- A novel in vivo screening method on ECDs, an application of alpha2u-globulin to EDC screening.
- A study on the development of a new in vitro assay targeted on the possible membrane-receptor mediated EDC effects.
- Combined effect of representative EDCs in uterotrophic, hershberger and modified one generation assays (contract study)
- Effects of endocrine disrupting chemicals on mouse gonad differentiation, spermgenesis and oogeuesis
- Development of in vitro system exhibiting human metabolic enzyme systems that modify the EDC molecules
- Development of screening system on the hormone receptor-mediated EDCs by yeast two-hybrid system.
- Studies on the semen quality in general population of Japan
- Effects of endocrine disrupting chemicals on central neuronal system and germ cells
- Effects of endocrine disrupting chemicals on neuronal stem-cell differentiation
- Effects of fetal and neonatal exposure to EDCs on the structural alterations of Hypothalamic nuclei and the influence on the reproduction.
- A study on the effect of Phthalates on reproduction.
- Basic studies on the OECD GL407 as an EDC assay
- Effects of endocrine disrupting chemicals on the thyroid carcinogenesis.
- Elucidation of toxicity mechanisms of endocrine disruptors that bind sex hormone receptors
- Developmental effects of endocrine disruptors on mouse reproductive organs
- Study of the mechanism of endocrine disruptors on gene expression of C. elegans
- Effects of EDCs on the uterine carcinogenesis model
- Mechanistic studies on the perturbation of organogenesis caused by endocrine disruptors
- 3D-QSAR of EDCs, by computer simulation system using the docking method.
- Biological and molecular aspects of EDCs with a special reference to 3D-QSAR analysis.
- Application of Surface Plasmon Resonanse method to high through put screening
- Effects of endocrine disruptors on chemokine production.
- Cross-talk of signal transduction of endocrine disruptors between arylhydrocarbone and steroid hormone receptors
- Development of a EDC screening system using sex-differentiation related gene expression in chick embryo
- Mechanism of adverse effects from endocrine disruptors
- Development of screening method of EDCs by the rodent intrauterine exposure models.
- Effects of endocrine disrupting chemicals on immune system
- Effects of estrogenic compounds on early development of the chick embryo
- The study on the effects of endocrine disrupting chemicals on steroid hormone receptors
- Aryl hydrocarbons as endocrine disruptors, a method development study.
- Development of EDC screening method using cell line transfected with human estrogen receptor gene.
- Analysis of testis-weight and spermatogenesis in Japanese men by using analytical data of necropsy
- Development of intrauterine exposure screening rodent model
- Refinement of Yeast Two-hybrid system on EDC screening
- Androgen receptor reporter gene assay system using a human cell line.
- A study on the effect of untrauterine exposure on the reproduction of the next generation (F2).
- Analysis of Polyglutamine neurotxicity by endocrine disrupting chemicals a as risk factor
- Analyses on the effect of ECDs on the estrogen metabolism and possible application to screening.
- Mechanism of possible human health effect of endocrine disrupting chemicals
- Effect of endocrine disruptors on highly integrated systems.
- Carcinogenic effect of endocrine disrupting chemicals
- Sex steroid hormone metabolism: enzyme and receptor expression in human tissues
- Development of detection system for endocrine disruptors with special reference to its mechanisms
- A study on the validation of high through put systems using reporter gene assay system and surface plasmon resonance method
- Molecular mechanism of receptor-mediated endocrine disrupting chemicals
- Development of effective bioassay system for endocrine dirsuptors in the workplace.
- The effects of hormones and EDCs on nueronal network
- Development of bioassay system of EDC effects on fish.
- Development of high-sensitivity analysis methods of endocrine disrupting chemicals
Ecological Effects
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