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Nitrofen Structural Formua
Nitrofen Structural Formua1941
CAS Number: 1836-75-5
Synonyms: Niclofen, Nip
Contaminant Type: Chemical

Nitrofen is the common name of the herbicide with the IUPAC name 2, 4-dichlorophenyl-p-nitrophenyl ether.  There are no current commercial uses for nitrofen.  Nitrofen was previously used as a contact herbicide for pre- and post-emergence control of annual grasses and broadleaf weeds on a variety of food and ornamental crops. [1941]  Nitrofen is no longer manufactured or sold in the United States [1941, 1942] 

It is not regulated in drinking water in the United States.  It was listed on the draft Contaminant Candidate List 3, but was removed before the list was finalized. 

Nitrofen is reasonably anticipated to be an endocrine disruptor [1944] and human carcinogen based on sufficient evidence of carcinogenicity experimental animals but no data are available in humans. [1941, 1942]  The primary routes of potential human exposure to nitrofen are inhalation, dermal contact, and ingestion. [1941, 1942]  

It is not known to degrade in water. 

Date of literature search: 2010

1941 National Institute of Environmental Health Science; 2010; Report on Carcinogens; http://iaspub.epa.gov/tdb_data_entry/pages/dataEntry/home.do;
1942 Natonal Library of Medicine ; 2010; Hazardous Substance Data Bank (HSDB); National Library of Medicine's TONET System; http://toxnet.nlm.nih.gov/cgi-bin/sis/search/f?./temp/~GR4627:1
1944 Hiratsuka, N., Wariihi, H., Tanaka, H.; 2001; Degradation of diphenyl ether herbicides by the lignin-degrading basidiomycee coriolus versicolor; Appl. Microbio. & Biotech.; 57: 563-571